Isabella D’este, daughter of the Duke of Ferrara and born into a life of luxury and art in Renaissance Italy. She’s beautiful and she loves art, so nothing would make her happier than to sit for the court’s painter, Leonardo Di Vinci. Of course, matters become complicated when her younger, less attractive sister Beatrice becomes the intended to Ludovico Sforza, the future Duke of Milan, the only man who can help Isabella achieve what she believes is to be her destiny. Despite being married to a man she loves, Isabella will do anything to get what she wants, even if it means besting her sister to tempt Ludovico and get to be the muse to one of the greatest painters in the world. However, with Ludovico’s nefarious plans to conquer Europe begin to fail and Isabella’s ambitions are the least of her worries, the sisters are forced to choose between family loyalty and survival in an increasingly perilous political environment.